Key result
BMI-adjusted ECG-LVH criteria detected more LVH but performed no better than traditional criteria for predicting all-cause (HR 1.18; 95% CI 1.06-1.32) or cardiovascular mortality.
Why the study?
Obesity attenuates the sensitivity of several ECG-LVH criteria leading to BMI-adjusted criteria, but their prognostic significance was not known.
Do BMI-adjusted ECG-LVH criteria improve prognostic value for all-cause and cardiovascular mortality compared to traditional criteria in a general population?
Cohort (n=7,812)
Yes
Do BMI-adjusted ECG-LVH criteria improve prognostic value for all-cause and cardiovascular mortality compared to traditional criteria in a general population?
Hazard Ratio: 1.18 (95% CI 1.06–1.32)
Adjusting ECG-LVH criteria for BMI increases detection rates but may result in the loss of prognostic information for all-cause and cardiovascular mortality.
No takes yet. Share an insight, caveat, or question.
BMI-adjusted ECG-LVH criteria should not yet supplant traditional ones for risk stratification; this cohort finding leaves open the need for prospective validation of prognostic value.
Afify et al. (2020) conducted a cohort in Left ventricular hypertrophy (n=7,812). BMI-adjusted ECG-LVH criteria vs. Traditional ECG-LVH criteria was evaluated on All-cause mortality (HR 1.18, 95% CI 1.06-1.32). BMI-adjusted ECG-LVH criteria detected more LVH but performed no better than traditional criteria for predicting all-cause (HR 1.18; 95% CI 1.06-1.32) or cardiovascular mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: