Dynamics of ventricular repolarisation in the congenital long QT syndromes.
Why the study?
Does altering sympathetic tone with isoprenaline, propranolol, or left stellate ganglion block affect ventricular repolarisation dynamics in patients with congenital long QT syndromes?
Population
8 patients with congenital long QT syndromes
Design
Case_series
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in congenital LQTS; challenges prior emphasis on repolarization dynamics but requires validation in larger cohorts.
Structured PICO
Does altering sympathetic tone with isoprenaline, propranolol, or left stellate ganglion block affect ventricular repolarisation dynamics in patients with congenital long QT syndromes?
P
Population
8 patients with congenital long QT syndromes
I
Intervention
Isoprenaline, propranolol, and left stellate ganglion block to alter sympathetic tone
O
Outcome
Dynamics of ventricular repolarisation (effect of changing heart rate on the QT interval and the duration of the right ventricular monophasic action potential)surrogate
In congenital long QT syndrome, impaired QT rate adaptation is uncommon, but when present, it can be normalized by beta blockade and left stellate ganglion block.
Cite This Study
Linker et al. (1991) studied this question.