Why the study?
What are the differential effects of estrogen and progesterone on AT1 receptor gene expression in vascular smooth muscle cells?
What are the differential effects of estrogen and progesterone on AT1 receptor gene expression in vascular smooth muscle cells?
Estrogen and progesterone have opposing effects on AT1 receptor expression in vascular smooth muscle cells, which may explain their counteracting effects on postmenopausal cardiovascular disease risk.
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May explain opposing estrogen-progestin effects on postmenopausal CVD risk; leaves open confirmation in human vascular studies.
Nickenig et al. (2000) studied this question.
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