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June 1, 1998Journal of Hypertension

Determinants of interindividual variation of renin and prorenin concentrations

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Population

710 adults, aged 52-69 years, participating in a 1994 reexamination of a previous population survey in…

Design

Cross-sectional

Authors

ADA.H. Jan DanserVascular MedicineFDFrans H.M. DerkxMichigan State UniversityMSMaarten A.D.H. SchalekampGeneral / Preventive / Lipids

Discussion

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Implication

Identifies multiple prorenin determinants; confirms prior reports but leaves clinical relevance hypothesis-generating.

Structured PICO

P
Population
710 adults (327 men and 383 women), aged 52-69 years, participating in a 1994 reexamination of a previous population survey in Bavaria.
O
Outcome
Plasma concentrations of renin and proreninsurrogate

Plasma prorenin and renin levels exhibit significant interindividual variation driven by sex, age, blood pressure, diabetes, and antihypertensive medications.

Cite This Study

Danser et al. (1998) studied this question.

synapsesocial.com/papers/6a1ed19c38eb9bccee7e7db4https://doi.org/10.1097/00004872-199816060-00017

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for tissue-specific activation of renal angiotensinogen mRNA expression in chronic stable experimental heart failure.1992 · 93 citations
  2. 2Atrial natriuretic factor inhibits isoproterenol- and furosemide-stimulated renin release in humans.1989 · 14 citations
  3. 3Sexual Dimorphism of Inactive Renin in Rat Plasma1990 · 13 citations
  4. 4Plasma Renin Activity and Plasma Prorenin Are Not Suppressed in Hypertensives Surviving to Old Age1996 · 17 citations
  5. 5Response of plasma prorenin and active renin to chronic and acute alterations of renin secretion in normal humans. Studies using a direct immunoradiometric assay.1989 · 86 citations