Key result
Mechanical thrombectomy resulted in similar rates of in-hospital death, significant bleed, vascular complication, or mechanical support compared to catheter directed lysis (11% vs 12%, p=0.5).
Why the study?
The study aimed to compare in-hospital outcomes of patients treated with either mechanical thrombectomy or catheter directed lysis for acute pulmonary embolism.
Does mechanical thrombectomy improve in-hospital outcomes compared to catheter directed thrombolysis in patients with acute pulmonary embolism?
Population
458 patients undergoing MT or CDL for acute PE between 2014 and 2021
Comparison
Mechanical thrombectomy (MT) vs catheter directed lysis (CDL)
Design
Multicenter retrospective cohort study
Authors
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Supports comparable in-hospital safety for mechanical thrombectomy versus lysis in acute PE; hypothesis-generating and should not yet change practice.
Cohort (n=458)
Yes
Does mechanical thrombectomy improve in-hospital outcomes compared to catheter directed thrombolysis in patients with acute pulmonary embolism?
Absolute Event Rate: 11% vs 12%
p-value: p=0.5
Mechanical thrombectomy and catheter-directed thrombolysis have similar in-hospital safety and efficacy profiles for acute pulmonary embolism, though mechanical thrombectomy may reduce ICU length of stay.
Inci et al. (2022) conducted a cohort in Acute pulmonary embolism (n=458). Mechanical thrombectomy vs. Catheter directed lysis was evaluated on Composite of in-hospital death, significant bleed, vascular complication, or need for mechanical support post-procedure (p=0.5). Mechanical thrombectomy resulted in similar rates of in-hospital death, significant bleed, vascular complication, or mechanical support compared to catheter directed lysis (11% vs 12%, p=0.5).
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