Key result
Sodium current inactivation feedback drives bistable planar and spiral waves in excitable media.
Transitions between different spiral wave behaviors via saddle-node bifurcation may be a candidate mechanism for transitions seen in cardiac arrhythmias.
We show that a positive feedback loop between sodium current inactivation and wave-front ramp-up speed causes a saddle-node bifurcation to result in bistable planar and spiral waves in electrically excitable media, in which both slow and fast waves are triggered by different stimulation protocols. Moreover, the two types of spiral wave conduction may interact to give rise to more complex spiral wave dynamics. The transitions between different spiral wave behaviors via saddle-node bifurcation can be a candidate mechanism for transitions widely seen in cardiac arrhythmias and neural diseases.
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Zhang et al. (2023) studied Cardiac arrhythmias and neural diseases. A positive feedback loop between sodium current inactivation and wave-front ramp-up speed causes a saddle-node bifurcation resulting in bistable planar and spiral waves in excitable media.
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