Key result
Quinidine therapy completely suppressed spontaneous ventricular fibrillation in a 37-year-old man with Brugada syndrome and arrhythmic storm.
Why the study?
Does quinidine prevent arrhythmic events in a patient with Brugada syndrome and arrhythmic storm?
Case Report (n=1)
Does quinidine prevent arrhythmic events in a patient with Brugada syndrome and arrhythmic storm?
Quinidine effectively suppressed arrhythmic storm in a patient with Brugada syndrome, supporting its role in the prophylaxis of arrhythmic events.
Supports quinidine in refractory Brugada storm; hypothesis-generating and leaves open need for controlled trials.
A 37-year-old man with Brugada syndrome (BrS) and arrhythmic storm is described. One month after implantation of a cardioverter-defibrillator he presented with recurrent appropriate shocks for spontaneous ventricular fibrillation (VF). Because of this arrhythmic storm, quinidine therapy was initiated with total suppression of all spontaneous arrhythmias. He had remained free of arrhythmias for 22 months since quinidine initiation. Two episodes of VF occurred after the patient stopped taking the medication. The patient resumed quinidine and has been free of VF for the last 3 months. This response to quinidine in a patient with symptomatic BrS supports its role in the prophylaxis of arrhythmic events in BrS.
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Márquez et al. (2005) conducted a case report in Brugada syndrome and arrhythmic storm (n=1). Quinidine vs. Off medication was evaluated on Suppression of spontaneous arrhythmias. Quinidine therapy completely suppressed spontaneous ventricular fibrillation in a 37-year-old man with Brugada syndrome and arrhythmic storm.
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