Key result
Isoprenaline infusion followed by oral quinidine successfully stabilized rhythm and prevented recurrent ventricular fibrillation in a patient with Brugada syndrome electrical storm over 1 year.
Why the study?
Does isoprenaline infusion followed by oral quinidine improve refractory ventricular fibrillation electrical storm in a patient with type 2 Brugada syndrome?
Case Report (n=1)
No
Does isoprenaline infusion followed by oral quinidine improve refractory ventricular fibrillation electrical storm in a patient with type 2 Brugada syndrome?
Isoprenaline infusion followed by oral quinidine successfully stabilized refractory ventricular fibrillation electrical storm in a patient with type 2 Brugada syndrome.
May stabilize refractory VF in Brugada storm; hypothesis-generating, prospective trials needed before adoption.
A 3-year-old man with an implanted cardioverter-defibrillator (ICD) for type 2 Brugada syndrome was admitted to coronary care unit with ventricular fibrillation electrical storm and consequent appropriate recurrent ICD shocks. The rhythm did not settle with conventional antiarrhythmics such as β-blockers and amiodarone. An isoprenaline infusion was set up with immediate stabilisation of rhythm. After a period of monitoring, the infusion was stopped and oral quinidine was started. He has remained free of problems for 1 year. This case-report summarises these novel treatments for electrical storm in Brugada syndrome and the mechanism behind them.
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Guy Furniss (2012) conducted a case report in Type 2 Brugada syndrome with ventricular fibrillation electrical storm (n=1). Isoprenaline infusion and oral quinidine vs. Conventional antiarrhythmics (beta-blockers and amiodarone) was evaluated on Stabilisation of rhythm and freedom from recurrent events. Isoprenaline infusion followed by oral quinidine successfully stabilized rhythm and prevented recurrent ventricular fibrillation in a patient with Brugada syndrome electrical storm over 1 year.
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