Key result
Isoprenaline and quinidine acutely stabilize Brugada storm, preventing recurrent ventricular arrhythmias through one year.
Why the study?
Management strategies for acute Brugada storm in district general hospitals are not well established, particularly regarding the use of isoprenaline and quinidine.
Case Report (n=1)
No
Isoprenaline is an effective and readily accessible therapy for stabilizing acute Brugada storm in district general hospitals, while quinidine is effective for long-term suppression.
Answers are grounded in this paper and cite their sources.
May aid acute Brugada storm management in select cases; leaves open generalizability without prospective data.
for primary prevention following extraction of a previous transvenous ICD due to infection. Investigations suggested a non-ST-elevation myocardial infarction. While awaiting coronary angiography, he developed a ventricular tachycardia (VT) storm with recurrent cardiac arrests over 30 minutes due to polymorphic VT, receiving seven S-ICD shocks. Defibrillation, isoprenaline and quinidine were employed to manage the polymorphic VT storm, permitting transfer to a tertiary centre for further investigations. Coronary angiography demonstrated an occluded marginal artery, which was managed medically. Isoprenaline was weaned following quinidine initiation, the S-ICD reactivated, and he was discharged. A year later, there have been no further ventricular arrhythmias while on quinidine. This case report demonstrates the effectiveness of isoprenaline, which is easily accessible and readily available in DGHs, in stabilising an acute Brugada storm. Quinidine allowed successful weaning from isoprenaline, but lack of availability limits its use. Finally, this case report highlights both the benefits and risks of primary prevention ICDs in BrS.
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A 2026 study conducted a case report in Brugada storm (n=1). Isoprenaline and quinidine was evaluated. Administration of isoprenaline and quinidine successfully stabilized an acute Brugada storm, with no further ventricular arrhythmias occurring over a one-year follow-up.
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