Key result
Oxidative stress with 0.1 mM hydrogen peroxide induced early afterdepolarization-mediated ventricular tachycardia and fibrillation in 94% of aged rat hearts, whereas young adult hearts exhibited no arrhythmias.
Why the study?
Does oxidative stress with hydrogen peroxide induce ventricular arrhythmias more readily in aged hearts compared to young hearts?
Does oxidative stress with hydrogen peroxide induce ventricular arrhythmias more readily in aged hearts compared to young hearts?
Absolute Event Rate: 94% vs 0%
Oxidative stress induces ventricular fibrillation and tachycardia in aged hearts, facilitated by intermediate levels of age-related fibrosis.
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Oxidative stress may preferentially trigger ventricular arrhythmias in aged hearts; hypothesis-generating for human age-related mechanisms.
Morita et al. (2009) studied Ventricular fibrillation susceptibility (n=76). Hydrogen peroxide (H2O2) vs. Young adult hearts was evaluated on Incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF). Oxidative stress with 0.1 mM hydrogen peroxide induced early afterdepolarization-mediated ventricular tachycardia and fibrillation in 94% of aged rat hearts, whereas young adult hearts exhibited no arrhythmias.
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