Key result
Senescent (24-month-old) isolated rat hearts had a significantly higher incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias and contracture compared to adult hearts.
Why the study?
Does advanced age increase the incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias in isolated rat hearts?
Does advanced age increase the incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias in isolated rat hearts?
Senescent rat hearts show a significantly higher incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias and contracture compared to adult hearts, suggesting a role for age-related alterations in calcium homeostasis.
Hypothesis-generating for age-related reperfusion vulnerability; leaves open translation to in vivo or clinical settings.
Reperfusion- and reoxygenation-induced ventricular tachyarrhythmias were studied on 6-month-old (adult) and 24-month-old (senescent) Langendorff perfused rat hearts. The incidence of arrhythmias was significantly higher in the group of senescent hearts. Furthermore, the reperfusion- and reoxygenation-induced contracture was also more frequent in the group of senescent hearts. The interrelation between contracture and arrhythmias might represent an indirect evidence to suggest that alterations in cell calcium homeostasis have an important role in the origin of both phenomena and, possibly, in their increased incidence in the senescent heart.
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Pahor et al. (2009) studied Reperfusion- and reoxygenation-induced ventricular tachyarrhythmias. Senescence (24-month-old hearts) vs. Adult (6-month-old hearts) was evaluated on Incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias. Senescent (24-month-old) isolated rat hearts had a significantly higher incidence of reperfusion- and reoxygenation-induced ventricular tachyarrhythmias and contracture compared to adult hearts.
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