Key result
Experimental rhinovirus type 2 infection caused more frequent and severe clinical symptoms in subjects after 5 months of polar isolation compared to non-isolated volunteers in England.
Why the study?
Does prolonged isolation in a small closed community increase clinical and virological sensitivity to rhinovirus type 2 infection?
RCT (n=47)
Double-blind
Double blind conditions with placebo or rhinovirus type 2
Yes
Does prolonged isolation in a small closed community increase clinical and virological sensitivity to rhinovirus type 2 infection?
Absolute Event Rate: 88.9% vs 33.3%
Prolonged isolation in a closed community appears to increase clinical and virological sensitivity to rhinovirus infection, potentially linked to a fall in nasal immunoglobulin concentration.
No takes yet. Share an insight, caveat, or question.
Prolonged isolation may warrant enhanced infection precautions in closed communities; extends RCT evidence on environmental effects on viral susceptibility.
Holmes et al. (1976) conducted an RCT in Experimental rhinovirus infection (n=47). Rhinovirus type 2 (RV2) DP29 vs. Non-isolated volunteers (Salisbury) or Placebo was evaluated on Clinical reactions to 10^5 TCID50 RV2 DP29. Experimental rhinovirus type 2 infection caused more frequent and severe clinical symptoms in subjects after 5 months of polar isolation compared to non-isolated volunteers in England.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: