Key result
In a patient-specific computer model, a lack of length dependence of tension regulation within the sarcomere was identified as a significant contributor to the efficacy of cardiac resynchronization.
Why the study?
Does length-dependent tension regulation affect the efficacy of CRT in a patient-specific computer model?
Does length-dependent tension regulation affect the efficacy of CRT in a patient-specific computer model?
Computational modeling suggests that patients with an effective Frank-Starling mechanism may derive minimal benefit from CRT because length-dependent tension facilitates stress homogenization despite electrical dyssynchrony.
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May limit CRT benefit with intact Frank-Starling mechanism; leaves open sarcomere modeling for resynchronization selection.
Niederer et al. (2010) studied Heart failure. Cardiac resynchronization therapy (CRT) was evaluated on Efficacy of CRT and homogenization of tension development and strain. In a patient-specific computer model, a lack of length dependence of tension regulation within the sarcomere was identified as a significant contributor to the efficacy of cardiac resynchronization.
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