Key result
Chronic hypertension without superimposed pre-eclampsia was associated with an increased risk of small for gestational age babies compared to the general population (10.9% vs 4.1%; OR 2.9, 95% CI 1.6-5.0).
Why the study?
Does chronic hypertension in pregnancy increase perinatal morbidity compared to the general obstetric population?
Cohort (n=155)
No
Does chronic hypertension in pregnancy increase perinatal morbidity compared to the general obstetric population?
Odds Ratio: 2.9 (95% CI 1.6–5)
Absolute Event Rate: 10.9% vs 4.1%
Chronic hypertension in pregnancy, even without superimposed pre-eclampsia, is associated with a significantly increased risk of delivering a small for gestational age baby.
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May support enhanced fetal surveillance in chronic hypertension; leaves open need for interventional trials to improve outcomes.
McCowan et al. (1996) conducted a cohort in Chronic hypertension in pregnancy (n=155). Chronic hypertension without superimposed pre-eclampsia vs. General obstetric population was evaluated on Small for gestational age babies (birthweight less than the fifth centile) (OR 2.9, 95% CI 1.6 to 5.0). Chronic hypertension without superimposed pre-eclampsia was associated with an increased risk of small for gestational age babies compared to the general population (10.9% vs 4.1%; OR 2.9, 95% CI 1.6-5.0).
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