What question did this study set out to answer?

To review evidence regarding alterations in adrenergic receptor density and responsiveness across cardiovascular tissues and circulating blood cells in hypertension.

August 1, 1990HypertensionOpen Access

Peripheral adrenergic receptors in hypertension.

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Authors

MMMartin C. MichelJohannes Gutenberg University Mainz OBO.‐E. BroddeEssen University Hospital PIPaul A. InselHeart Failure & Transplant

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Implication

Literature review reveals altered adrenergic receptor density and signaling in hypertension, indicating that defective adenylyl cyclase pathways contribute to elevated blood pressure.

Key Points

To review evidence regarding alterations in adrenergic receptor density and responsiveness across cardiovascular tissues and circulating blood cells in hypertension.
Synthesized findings from human hypertensive patients and multiple animal models of hypertension.
Evaluated alpha- and beta-adrenergic receptor characteristics in cardiovascular organs (heart, vascular smooth muscle, kidney) and circulating tissues (lymphocytes, platelets).
Alpha-adrenergic receptor density is regulated by catecholamines, dietary sodium, and genetics, with elevated renal alpha-adrenergic receptors identified as a possible cause of genetic essential hypertension.
Beta-adrenergic receptor responsiveness is desensitized despite inconsistent changes in receptor numbers, indicating an underlying defect in adenylyl cyclase signal transduction rather than simple receptor loss.

Cite This Study

Michel et al. (1990) studied this question.

synapsesocial.com/papers/6a1f0234331edacc706b5757 https://doi.org/10.1161/01.hyp.16.2.107

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Implication

Literature review reveals altered adrenergic receptor density and signaling in hypertension, indicating that defective adenylyl cyclase pathways contribute to elevated blood pressure.

Peripheral adrenergic receptors in hypertension.

Discussion

Member takes

Implication

Key Points

Cite This Study

Peripheral adrenergic receptors in hypertension.

Discussion

Member takes

Implication

Key Points

Cite This Study

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