Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2001American Journal of HypertensionOpen Access

Role of α2-adrenergic receptors in hypertension

View Full Paper
Ask AI
Bookmark
Share

Population

Genetically engineered mice with disrupted genes for alpha2-AR subtypes, and rats treated with…

Design

Review

Authors

HGHaralambos Gavras

Discussion

Loading...

Member takes

Overview

Highlights potential for alpha2B-AR selective agents in salt-sensitive hypertension; leaves open prospective clinical validation.

Structured PICO

P
Population
Genetically engineered mice with disrupted genes for alpha2-AR subtypes, and rats treated with antisense-oligodeoxynucleotides targeting specific gene sequences.
I
Intervention
Salt loading and evaluation of alpha2-AR subtypes (alpha2A, alpha2B, alpha2C) via genetic disruption or antisense-oligodeoxynucleotides.
O
Outcome
Hemodynamic function and sympathetic nervous system response to salt loading.surrogate

Different alpha2-adrenergic receptor subtypes have distinct roles in blood pressure regulation and the hypertensive response to salt loading.

Cite This Study

Haralambos Gavras (2001) studied this question.

synapsesocial.com/papers/6a8af180c12eaf65c8b1f065https://doi.org/10.1016/s0895-7061(01)02085-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of α2-Adrenergic Receptor Subtypes in the Acute Hypertensive Response to Hypertonic Saline Infusion in Anephric Mice2000 · 42 citations
  2. 2Models of Experimental Hypertension in Mice1996 · 175 citations
  3. 3Effects of Antisense Oligodeoxynucleotide Targeting of the α2B-Adrenergic Receptor Messenger RNA in the Central Nervous System2001 · 33 citations
  4. 4Sodium Chloride-induced Partial Inhibition In Vivo Of Alpha2-Adrenoceptor Agonist Function1985 · 28 citations
  5. 5Responsiveness of locus ceruleus neurons in hypertensive rats to vasopressin.1987 · 19 citations