December 1, 2001Journal of Hypertension

The α2-adrenergic receptors in hypertension and heart failure: experimental and clinical studies

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Population

Animals submitted to genetic manipulations or gene treatment, and patients with ischemic heart disease…

Design

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Authors

AMAthanasios ManolisGeneral Cardiology HGHaralambos GavrasGeneral / Preventive / Lipids

Discussion

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Implication

Alpha2-AR subtype selectivity may merit drug development for HF and IHD; leaves open clinical translation from animal and small-trial data.

Structured PICO

Population

Animals submitted to genetic manipulations or gene treatment, and patients with ischemic heart disease, acute or chronic heart failure, acute myocardial infarct, or hypertensive cardiomyopathy

Intervention

Alpha2-AR agonist clonidine (clinical) and genetic manipulation of alpha2A/alpha2B receptors (experimental)

Selective activation of alpha2A-AR or blockade of alpha2B-AR represents a potential future therapeutic strategy for hypertension, ischemic heart disease, and heart failure.

Cite This Study

Manolis et al. (2001) studied this question.

synapsesocial.com/papers/6a7dcf331b4d300315045c1a https://doi.org/10.1097/00004872-200112000-00001

Topics

Hypertension management

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Implication

Alpha2-AR subtype selectivity may merit drug development for HF and IHD; leaves open clinical translation from animal and small-trial data.

The α2-adrenergic receptors in hypertension and heart failure: experimental and clinical studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The α2-adrenergic receptors in hypertension and heart failure: experimental and clinical studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider