April 1, 1994Journal of Hypertension

Genetic analysis of alpha2-adrenergic receptors and blood pressure using Dahl salt-sensitive rats

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Population

Inbred Dahl salt-sensitive rats crossed with inbred Dahl salt-resistant rats and control strains, producing…

Design

Preclinical

Authors

DGDwight I. GinnUniversity of Toledo Medical Center CBCarlos BaptistaUniversity of Toledo Medical Center KAKiswar Y. AlamOhio Department of Health

Discussion

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Implication

Does not support these receptors as BP regulators in this model; leaves open their role in human hypertension.

Structured PICO

Population

Inbred Dahl salt-sensitive (SS/Jr) rats crossed with inbred Dahl salt-resistant (SR/Jr) rats and control strains, producing F2 populations raised on a high-salt diet

Intervention

Genotyping at loci for three different subtypes of alpha 2-adrenergic receptors (classes I, II, and III)

Outcome

Blood pressuresurrogate

This preclinical study found no evidence that alpha 2-adrenergic receptor genes cosegregate with blood pressure in Dahl salt-sensitive rats.

Limitations

Classes II and III alpha 2-adrenergic receptors could each be tested in only one population, making the negative result not definitive.

Cite This Study

Ginn et al. (1994) studied this question.

synapsesocial.com/papers/6a892e97f65c7b03f94d2a9f https://doi.org/10.1097/00004872-199404000-00005

Topics

Hypertension management

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Genetic analysis of alpha2-adrenergic receptors and blood pressure using Dahl salt-sensitive rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Genetic analysis of alpha2-adrenergic receptors and blood pressure using Dahl salt-sensitive rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider