September 1, 1994Journal of Hypertension

Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure

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Population

Rat models including F2 populations involving the SS/Jr rat, inbred Dahl salt-sensitive strain, Lyon…

Comparison

Genetic analysis of the angiotensin II receptor… vs Normotensive control strains

Design

Preclinical

Authors

ADAlan Y. DengUniversité de Montréal JRJohn P. RappUniversity of Toledo

Discussion

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Implication

AT1B unlikely causal for BP variation in rat models; leaves open nearby QTL mapping before any human translation.

Structured PICO

Population

Rat models including F2 populations involving the SS/Jr rat, inbred Dahl salt-sensitive (SS/Jr) strain, Lyon hypertensive (LH) strain, Lyon normotensive (LN) strain, and various control strains

Intervention

Genetic analysis of the angiotensin II receptor AT1B locus (cosegregation analysis and sequencing of coding regions)

Comparator

Normotensive control strains (e.g., Lyon normotensive strain)

Outcome

Cosegregation of AT1B alleles with systolic blood pressure and nucleotide differences in the AT1B coding regionssurrogate

The AT1B gene is unlikely to be the candidate gene causing blood pressure differences in these hypertensive rat models.

Cite This Study

Deng et al. (1994) studied this question.

synapsesocial.com/papers/6a6fafeaac440176ef285889 https://doi.org/10.1097/00004872-199409000-00002

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Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider