Why the study?
Is the AT2-R gene C4599A polymorphism associated with hypertension in Japanese populations?
Population
Men and women from two large Japanese populations
Comparison
AT2-R gene polymorphisms (specifically C4599A) vs Different AT2-R genotypes
Design
Cross-sectional
Authors
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Association in premenopausal Japanese women should not change practice; hypothesis-generating for sex-specific AT2-R variants in hypertension.
Is the AT2-R gene C4599A polymorphism associated with hypertension in Japanese populations?
The AT2-R gene C4599A polymorphism exhibits a female-specific association with hypertension in Japanese populations, particularly in premenopausal women.
Jin et al. (2003) studied this question.
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