Why the study?
Do genetic variants of angiotensin II receptors (AT1R and AT2R) affect cardiovascular risk in healthy men?
Population
2579 healthy UK men, mean age 56.1+/-3.5 years
Comparison
AT1R1166A>C and X chromosome located AT2R1675A>G… vs Alternative genotypes/alleles
Design
Cohort
Follow-up
median 10.1 years
Authors
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May refine cardiovascular risk stratification beyond blood pressure; hypothesis-generating for genotype-guided approaches pending validation.
Do genetic variants of angiotensin II receptors (AT1R and AT2R) affect cardiovascular risk in healthy men?
The AT1R1166CC genotype increases cardiovascular risk independent of blood pressure, while the AT2R1675A allele modulates blood pressure-associated risk, supporting a protective role for the inducible AT2R.
Jones et al. (2003) studied this question.
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