December 2, 1994European Heart Journal

Genetic Polymorphisms of the Angiotensin II type 1 (AT1) Receptor Gene

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Why the study?

Are genetic polymorphisms of the AT1 receptor gene associated with cardiovascular disease?

Structured PICO

Are genetic polymorphisms of the AT1 receptor gene associated with cardiovascular disease?

Population

Individuals with no previous history of cardiovascular complaint or immediate family history (controls), and patients with essential hypertension (n=20), coronary artery disease (n=16), hypertrophic cardiomyopathy (n=12), or dilated cardiomyopathy (n=21).

Intervention

Polymerase chain reaction (PCR) and non-radioactive sequencing of the AT1 gene to identify polymorphisms.

Outcome

Presence of polymorphisms within the coding region of the AT1 gene and their association with cardiovascular disease.surrogate

Preliminary findings identified novel polymorphisms in the AT1 receptor gene but found no association between the C/T573 polymorphism and cardiovascular diseases.

Limitations

Preliminary study
Further studies needed to determine extent of association

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support C/T573 testing for CVD risk; leaves open whether other AT1 variants contribute.

Cite This Study

Rolfs et al. (1994) studied this question.

synapsesocial.com/papers/6a83b0af4b7d31ae448dcd66 https://doi.org/10.1093/eurheartj/15.suppl_d.108

Topics

Heart failure HFrEF treatment Hypertension management Hypertrophic cardiomyopathy

View Full Paper

Ask AI

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Genetic Polymorphisms of the Angiotensin II type 1 (AT1) Receptor Gene

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Genetic Polymorphisms of the Angiotensin II type 1 (AT1) Receptor Gene

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider