Population
Dahl-Iwai salt-sensitive or resistant rats
Comparison
High-salt diet from 4 to 6 or 10 weeks of age vs Low-salt diet (0.3% NaCl)
Design
Preclinical
Follow-up
up to 6 weeks (from 4 to 10 weeks of age)
Authors
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May inform mechanisms of early salt-sensitive hypertension in animal models; leaves open translation to human disease or therapy.
High salt intake modulates alpha2-adrenoceptors in the brainstem and kidney during the early phase of salt-induced hypertension development in Dahl-Iwai salt-sensitive rats.
Tozawa et al. (1995) studied this question.
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