Key result
High-sodium diet increases renal alpha 2-adrenoceptors while selectively decreasing cerebral densities in normotensive rats.
Why the study?
The effect of high versus normal sodium diet on cerebral and renal alpha-adrenoceptors in Sabra hypertensive and normotensive rats was investigated to understand mechanisms related to salt-induced hypertension.
Does a high sodium diet alter cerebral and renal alpha-adrenoceptor densities in Sabra hypertensive and normotensive rats?
Population
Sabra hypertensive (SBH) and normotensive (SBN) rats
Comparison
High (8%) sodium diet versus normal (0.2%) sodium diet
Design
Preclinical experimental study
Follow-up
2 and 5 weeks
Authors
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Suggests adaptive cerebral adrenoceptor changes in normotensive rats on high salt; leaves open translation to human salt-sensitive hypertension.
Does a high sodium diet alter cerebral and renal alpha-adrenoceptor densities in Sabra hypertensive and normotensive rats?
In normotensive rats, a high-sodium diet decreases cerebral alpha 2-adrenoceptors, potentially representing an adaptive mechanism against salt-induced hypertension.
Diop et al. (1984) studied Hypertension. High sodium diet vs. Normal (0.2%) sodium diet was evaluated on Cerebral and renal alpha-adrenoceptor densities. A high (8%) sodium diet increased renal alpha 2-adrenoceptor densities in both strains, but markedly decreased cerebral alpha 2-adrenoceptors only in normotensive rats.
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