January 1, 1981Clinical and Experimental Hypertension

Distinguishing Traits in the Sabra Hypertension-prone (SBH) and Hypertension-resistant (SBN) Rats

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Population

Sabra Hypertension-prone and Hypertension-resistant rats derived from the Hebrew University SABRA rats

Comparison

Doca-salt treatment vs Strain comparison and untreated controls

Design

Preclinical

Authors

DBDrori Ben‐IshayHôpital Necker-Enfants Malades NZN. ZamirKhyber Teaching Hospital GFGiora Feurstein

Discussion

Member takes

Implication

Does not yet guide clinical hypertension care; leaves open medullary noradrenergic mechanisms in salt-resistant models.

Structured PICO

Population

Sabra Hypertension-prone (SBH) and Hypertension-resistant (SBN) rats derived from the Hebrew University SABRA rats

Intervention

Doca-salt treatment

Comparator

Strain comparison (SBH vs SBN) and untreated controls

Outcome

Central and peripheral noradrenaline (NA) concentration, tyrosine hydroxylase activity, NA-induced cAMP generation, and blood pressuresurrogate

Resistance to hypertension in SBN rats is associated with decreased noradrenaline turnover in the medulla oblongata and reduced activity of cardiac neuronal sympathetic endings.

Cite This Study

Ben‐Ishay et al. (1981) studied this question.

synapsesocial.com/papers/6a886cd94231b321a876f80c https://doi.org/10.3109/10641968109033698

Topics

Hypertension management

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Distinguishing Traits in the Sabra Hypertension-prone (SBH) and Hypertension-resistant (SBN) Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Distinguishing Traits in the Sabra Hypertension-prone (SBH) and Hypertension-resistant (SBN) Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider