Key result
Higher CVH score linked to ~11% lower all-cause mortality, mediated by plasma proteins.
Why the study?
The mechanisms underlying the protective associations between cardiovascular health and all-cause mortality have not been fully elucidated.
Does higher cardiovascular health (Life's Simple 7 score) reduce all-cause mortality in older adults?
Cohort (n=703)
Does higher cardiovascular health (Life's Simple 7 score) reduce all-cause mortality in older adults?
Hazard Ratio: 0.89
p-value: p=1.17 x 10^-5
Higher cardiovascular health promotes longevity in older adults, potentially mediated by the suppression of inflammation, complement, coagulation, and GH/IGF pathways.
Reinforces CVH importance for longevity in older adults; extends evidence via protein mediators but leaves causal roles open.
Measures of cardiovascular health (CVH) assessed by a combination of behavioral and biological factors has shown protective associations with all-cause mortality. The mechanisms underlying these associations have not been fully elucidated. In this study, we characterized the plasma proteomics profile of CVH and tested whether specific proteins mediated the associations between CVH and all-cause mortality in participants of the InCHIANTI study. Of the 1301 proteins tested, 92 proteins were associated with CVH (22 positively, 70 negatively). Proteins most strongly associated with CVH included leptin (LEP), fatty acid binding protein 3 (FABP3), Angiopoietin-2 (ANGPT2), and growth-differential factor 15 (GDF15). Of the 92 CVH-associated proteins, 33 proteins significantly mediated the associations between CVH and all-cause mortality, with percent mediation ranging from 5 to 30%. The most significant mediating proteins were GDF15 and insulin-like growth factor 2 (IGFBP2). Proteins associated with better CVH were enriched for proteins that reflect the suppression of the complement coagulation and GH/IGF pathways.
No takes yet. Share an insight, caveat, or question.
Tanaka et al. (2023) conducted a cohort in Older adults (n=703). Cardiovascular health (Life's Simple 7 score) vs. Lower cardiovascular health score was evaluated on All-cause mortality (HR 0.89, p=1.17 x 10^-5). Higher cardiovascular health score was inversely associated with all-cause mortality (HR 0.89, p=1.17 x 10^-5), with 33 plasma proteins significantly mediating this association.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: