Key result
Exposure to high glucose (30 mmol/L) for 4 weeks significantly increased extracellular matrix production in mesangial cells, with more pronounced effects in the Milan normotensive strain.
Why the study?
Does high glucose exposure increase extracellular matrix production and cell proliferation in mesangial cells from MNS compared to MHS rats?
Does high glucose exposure increase extracellular matrix production and cell proliferation in mesangial cells from MNS compared to MHS rats?
High glucose unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from a glomerulosclerosis-susceptible normotensive rat strain.
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Hypothesis-generating for genetic susceptibility in diabetic glomerulosclerosis; does not support clinical practice changes.
Pugliese et al. (1997) studied Diabetic glomerular disease. High glucose concentration vs. Normal glucose concentration (5.5 mmol/L) was evaluated on Extracellular matrix and cytokine production and cell proliferation. Exposure to high glucose (30 mmol/L) for 4 weeks significantly increased extracellular matrix production in mesangial cells, with more pronounced effects in the Milan normotensive strain.