Why the study?
Does antihypertensive therapy with enalapril or hydralazine prevent glomerular injury in a rat model of experimental diabetes?
Population
Munich-Wistar rats with streptozocin-induced diabetes receiving daily insulin injections
Comparison
Enalapril or hydralazine vs Untreated diabetic rats and age-matched…
Design
Preclinical, assigned to one of three groups
Follow-up
up to 12 months
Authors
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Glomerular pressure reduction, not systemic hypotension, prevents diabetic glomerular injury in rats; leaves open translation to human diabetic kidney disease.
Does antihypertensive therapy with enalapril or hydralazine prevent glomerular injury in a rat model of experimental diabetes?
Normalization of glomerular pressure with enalapril, but not systemic hypotension with hydralazine, prevents glomerular injury in experimental diabetes.
Fujihara et al. (1992) studied this question.
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