December 1, 1999Journal of Hypertension

Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats

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Why the study?

Does spirapril prevent the progression of renal damage compared to a triple antihypertensive combination in hypertensive diabetic rats?

Population

Hypertensive diabetic rats

Comparison

Angiotensin-converting enzyme inhibitor spirapril vs Antihypertensive triple drug combination of…

Design

Preclinical

Authors

BFBruno FabrisOspedale di Cattinara RCRiccardo CandidoUniversity of Trieste LAL. ArminiUniversity of Trieste

Discussion

Member takes

Implication

Supports ACE inhibition for renoprotection in diabetic models independent of BP; leaves open human translation.

Structured PICO

Does spirapril prevent the progression of renal damage compared to a triple antihypertensive combination in hypertensive diabetic rats?

Population

Hypertensive diabetic rats

Intervention

Angiotensin-converting enzyme (ACE) inhibitor spirapril (SPI)

Comparator

Antihypertensive triple drug combination of hydralazine, reserpine and hydrochlorothiazide (HRH), no specific therapy, and non-diabetic hypertensive controls

Outcome

Kidney function, proteinuria and renal structure (systolic blood pressure, 24 h urinary total protein, glomerular filtration rate, glomerular area, proximal tubular area and glomerular sclerosis)surrogate

ACE inhibition with spirapril prevents glomerulosclerosis and renal hypertrophy more effectively than standard antihypertensive therapy in hypertensive diabetic rats, independent of blood pressure lowering.

Cite This Study

Fabris et al. (1999) studied this question.

synapsesocial.com/papers/6a8a53014c30e1095aeca94c https://doi.org/10.1097/00004872-199917121-00023

Topics

Hypertension management

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Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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