Why the study?
Does enalapril improve kidney function and glomerular ultrastructure compared to hydralazine and metoprolol in hypertensive diabetic and nondiabetic rats?
Population
Spontaneously hypertensive (SHR) rats, diabetic (streptozocin-induced at 8 weeks of age) and nondiabetic
Comparison
Enalapril administered in drinking water from… vs Hydralazine and metoprolol administered in…
Design
Preclinical
Follow-up
32 weeks
Authors
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No ACEI-specific renoprotection beyond BP lowering in diabetic hypertensive rats; leaves open translation to human disease and need for clinical trials.
Does enalapril improve kidney function and glomerular ultrastructure compared to hydralazine and metoprolol in hypertensive diabetic and nondiabetic rats?
In a rat model of genetic hypertension and experimental diabetes, ACE inhibition with enalapril offered no specific renoprotective benefit over conventional antihypertensive therapy with hydralazine and metoprolol.
Cooper et al. (1990) studied this question.
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