Why the study?
Do different classes of antihypertensive drugs (ACEi, ARB, calcium antagonist) differentially affect vascular hypertrophy and albumin permeability in a rat model of hypertension and diabetes?
Population
8-week-old spontaneously hypertensive rats with streptozotocin-induced diabetes mellitus
Comparison
Ramipril, valsartan, or lacidipine for 3 weeks vs No treatment
Design
Preclinical, randomized
Follow-up
3 weeks
Authors
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Suggests caution with lacidipine in comorbid hypertension-diabetes; leaves open class-specific vascular effects in humans.
Do different classes of antihypertensive drugs (ACEi, ARB, calcium antagonist) differentially affect vascular hypertrophy and albumin permeability in a rat model of hypertension and diabetes?
In a rat model of hypertension and diabetes, the calcium antagonist lacidipine had unfavorable effects on vascular hypertrophy and albumin permeability compared to ACE inhibition or ARB therapy.
U LENNARTHULTHEN (1996) studied this question.
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