Why the study?
Does blockade of the renin-angiotensin system, vasopeptidase inhibition, or calcium channel antagonism reduce cardiovascular hypertrophy in diabetic spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) with streptozotocin-induced diabetes
Comparison
Captopril, valsartan, combination of captopril… vs Untreated diabetic SHR
Design
Preclinical
Follow-up
32 weeks
Authors
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Hypothesis-generating for dual RAS blockade in diabetic hypertension; leaves open clinical translation and should not change practice.
Does blockade of the renin-angiotensin system, vasopeptidase inhibition, or calcium channel antagonism reduce cardiovascular hypertrophy in diabetic spontaneously hypertensive rats?
Optimizing blockade of the renin-angiotensin system with a combination of ACE inhibition and AT1 receptor antagonism provides superior antitrophic effects on cardiac and vascular hypertrophy in diabetic hypertensive rats compared to calcium channel blockade.
Lassila et al. (2003) studied this question.
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