Why the study?
Does prevention of hypertension with or without renin-angiotensin system inhibition prevent nephrin loss and albuminuria in early experimental diabetes?
Population
4-week-old spontaneously hypertensive rats with streptozotocin-induced diabetes and genetically normotensive…
Comparison
Captopril, losartan, or triple therapy for 20 days vs No treatment
Design
Preclinical, Randomized
Follow-up
20 days
Authors
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Supports BP lowering for nephrin preservation and albuminuria reduction in diabetic models regardless of RAS inhibition; leaves open human translation.
Does prevention of hypertension with or without renin-angiotensin system inhibition prevent nephrin loss and albuminuria in early experimental diabetes?
Prevention of hypertension, regardless of renin-angiotensin system inhibition, restores nephrin expression and prevents albuminuria in early experimental diabetes.
Amazonas et al. (2007) studied this question.
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