Key result
Left ventricular global longitudinal strain >-12.65% independently predicted adverse cardiac outcomes (HR 3.58) in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Why the study?
The study sought to investigate left ventricular global myocardial strain and involvement characteristics in patients with ARVD/C and evaluate their predictive value for adverse cardiac events.
Does left ventricular global myocardial strain assessed by CMR feature tracking predict adverse cardiac events in patients with ARVD/C?
Comparison
Patients with ARVD/C vs healthy controls
Design
Retrospective observational cohort study
Follow-up
Mean 4.10 ± 1.77 years
Authors
Loading...
May refine ARVD/C risk stratification; hypothesis-generating for CMR feature tracking validation in larger cohorts.
Observational (n=94)
No
Does left ventricular global myocardial strain assessed by CMR feature tracking predict adverse cardiac events in patients with ARVD/C?
Hazard Ratio: 3.58 (95% CI 1.14–11.25)
p-value: p=0.029
Left ventricular global longitudinal strain assessed by CMR feature tracking is significantly impaired in ARVD/C patients and serves as an independent predictor of adverse cardiac events.
Shen et al. (2019) conducted an observational in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) (n=94). Left ventricular global longitudinal strain (LV GLS) > -12.65% vs. LV GLS ≤ -12.65% was evaluated on Composite of sustained ventricular tachycardia or fibrillation, cardiac death, resuscitated cardiac arrest, heart transplantation, and appropriate implantable cardioverter-defibrillator shock (HR 3.58, 95% CI 1.14 to 11.25, p=0.029). Left ventricular global longitudinal strain >-12.65% independently predicted adverse cardiac outcomes (HR 3.58) in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: