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May 1, 2010Epidemiology and HealthOpen Access

Improvements in regular exercise significantly reduced the risk of progression to hypertension in both men (HR 0.653, 95% CI 0.593-0.718) and women (HR 0.534, 95% CI 0.426-0.669).

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Why the study?

Do improvements in cardiovascular disease risk factors prevent the progression from prehypertension to hypertension in adults aged 30 to 54?

Population

16,229 subjects, aged 30 to 54, with new onset prehypertension at baseline in a biennial national medical…

Comparison

Improvements in cardiovascular disease risk… vs Continuous presence of cardiovascular disease…

Design

Cohort

Follow-up

8 years

Authors

SKSoo‐Jeong KimJLJakyoung LeeSJSun Ha Jee

Discussion

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Overview

Supports exercise promotion in prehypertension; leaves open causal confirmation from randomized trials.

Structured PICO

Do improvements in cardiovascular disease risk factors prevent the progression from prehypertension to hypertension in adults aged 30 to 54?

P
Population
16,229 subjects, aged 30 to 54, with new onset prehypertension (PreHTN) at baseline (1994-1996) in a biennial national medical exam from the Korean Cancer Prevention Study (KCPS).
I
Intervention
Improvements in cardiovascular disease risk factors (smoking cessation, reducing alcohol intake, starting regular exercise, weight loss, and lowering total cholesterol) over an 8-year period.
C
Comparator
Continuous presence of cardiovascular disease risk factors (continuous smoking, continuous drinking, continuous non-exercise, consistent obesity, and consistently high total cholesterol).
O
Outcome
Progression from prehypertension to hypertension (HTN) over an 8-year follow-up.surrogate

Improvements in modifiable cardiovascular risk factors, particularly adopting regular exercise, significantly reduce the risk of progressing from prehypertension to hypertension.

Limitations

  • No information on antihypertensive medications in this population
  • Misclassification bias could have arisen from measurement error because examinations were carried out at various hospitals with varying laboratory techniques
  • Categorization of individuals was based on the average BP obtained from a single BP measurement in 1994 and 1995
  • No information on possible changes during the intervening period between biennial measurements

Cite This Study

Kim et al. (2010) studied this question.

synapsesocial.com/papers/6a1f4392d03d2b72e7233cc2https://doi.org/10.4178/epih/e2010003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence and risk factors for progression from prehypertension to hypertension: a 12-year Korean Cohort Study2020 · 23 citations
  2. 2Progression Rate From New-Onset Pre-Hypertension to Hypertension in Korean Adults2010 · 29 citations
  3. 3Lifestyle Factors, Sociodemographic Characteristics and Incident Hypertension: A Prospective Analysis of the Korean National Health Insurance Service Sample Cohort2024 · 3 citations
  4. 4Progression from Prehypertension to Hypertension and Risk of Gastrointestinal Cancer—A Nationwide Health-Screening Cohort Study2026
  5. 5Rates and Related Factors of Progression to Hypertension among Prehypertensive Local Residents Aged 45 or Over in Chuncheon City: Hallym Aging Study from a Community-Based Cross-Sectional Study2008 · 8 citations