Key result
Intramyocardial hemorrhage in STEMI patients was associated with lower TRAP-induced platelet aggregation in the subacute phase (P = .004).
Why the study?
Is platelet reactivity associated with intramyocardial hemorrhage in patients with STEMI undergoing primary PCI?
Observational (n=49)
Is platelet reactivity associated with intramyocardial hemorrhage in patients with STEMI undergoing primary PCI?
p-value: p=.004
Intramyocardial hemorrhage in STEMI patients is associated with more potent inhibition of platelet aggregation in the subacute phase.
May reflect platelet heterogeneity in hemorrhagic STEMI; leaves open whether this informs antiplatelet strategies.
The aim of the study was to analyze the relation between platelet reactivity and intramyocardial hemorrhage (IMH) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Platelet reactivity was measured in 49 patients with means of impedance aggregometry (Multiplate) before reperfusion and repeated in the subacute phase of STEMI. Cardiovascular magnetic resonance was used to detect IMH, which was found in 16 (33%) patients. There were no differences in platelet reactivity between patients with and without IMH before reperfusion. Reassessment in the subacute phase of STEMI demonstrated that patients with IMH had lower thrombin receptor activating peptide (TRAP)-induced platelet aggregation (P = .004) and trends toward lower values of ristocetin and collagen-induced platelet aggregation (P = .09 and P = .07). The TRAP-induced platelet aggregation and initial perfusion grade were the factors independently associated with IMH. Intramyocardial hemorrhage is related to more potent inhibition of platelet aggregation in the subacute phase of STEMI.
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Małek et al. (2013) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=49). Intramyocardial hemorrhage vs. No intramyocardial hemorrhage was evaluated on TRAP-induced platelet aggregation in the subacute phase (p=.004). Intramyocardial hemorrhage in STEMI patients was associated with lower TRAP-induced platelet aggregation in the subacute phase (P = .004).
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