August 1, 1993AJP Heart and Circulatory Physiology

Spatial features of calcium transients during early and delayed afterdepolarizations

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Population

Enzymatically isolated guinea pig ventricular myocytes (n=26)

Design

Preclinical

Authors

MMMakoto MiuraRakuwakai Otowa Hospital NINobumasa IshideUniversity of Washington HOHitoshi OdaMorinomiya University of Medical Sciences

Discussion

Member takes

Implication

Highlights potential mechanistic differences between DADs and EADs; leaves open clinical relevance in human arrhythmias.

Structured PICO

Population

Enzymatically isolated guinea pig ventricular myocytes (n=26)

Intervention

Superfusion with potassium-free Tyrode solution to induce delayed afterdepolarizations (DADs) and early afterdepolarizations (EADs)

Outcome

Spatial features of the increase in intracellular Ca2+ concentration ([Ca2+]i) during DADs and EADssurrogate

The spatial features of intracellular calcium increases differ between DADs (heterogeneous waves) and EADs (synchronous changes), suggesting different underlying ionic mechanisms.

Cite This Study

Miura et al. (1993) studied this question.

synapsesocial.com/papers/6a1f65dbd09bc027e483685d https://doi.org/10.1152/ajpheart.1993.265.2.h439

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Spatial features of calcium transients during early and delayed afterdepolarizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Spatial features of calcium transients during early and delayed afterdepolarizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider