Key result
Physical injury to the sarcolemma of rat myocytes induced asynchronous but organized dynamic changes in regional cytoplasmic calcium concentrations, including propagated calcium waves.
Population
Myocytes isolated from rat left ventricle, loaded with acetoxymethyl ester of fura-2
Design
Preclinical
Authors
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Hypothesis-generating for post-injury calcium dysregulation; human validation required before clinical relevance.
In rat ventricular myocytes, physical injury induces asynchronous but organized calcium waves governed by propagation, resetting, and refractory periods.
Ishide et al. (1992) studied this question. Physical injury to the sarcolemma was evaluated on Changes in regional cytoplasmic calcium concentrations ([Ca2+]i). Physical injury to the sarcolemma of rat myocytes induced asynchronous but organized dynamic changes in regional cytoplasmic calcium concentrations, including propagated calcium waves.
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