Key result
Intracellular calcium waves directly cause subcellular spatially discordant alternans, sudden repolarization changes, and early afterdepolarizations, linking them to a variety of arrhythmogenic phenomena.
Intracellular calcium waves directly cause a variety of arrhythmogenic phenomena, including spatially discordant alternans and early afterdepolarizations, which are relevant to arrhythmias in the intact heart.
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Highlights calcium waves as arrhythmia triggers in cellular models; leaves open translation to intact-heart arrhythmias in vivo.
Xie et al. (2009) studied Arrhythmogenesis (n=38). Bay K 8644 and isoproterenol vs. Control conditions was evaluated on Development of subcellular spatially discordant alternans (SDA). Intracellular calcium waves directly cause subcellular spatially discordant alternans, sudden repolarization changes, and early afterdepolarizations, linking them to a variety of arrhythmogenic phenomena.
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