Key result
High-speed ratiometric imaging revealed that [Ca2+]i waves propagate at a constant velocity of typically 100 microns/s at 22 degrees C, with a spatially steep wave front rising from 500 to 1200 nM.
Population
Single voltage-clamped mammalian cardiac cells
Design
Preclinical
Authors
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Cellular wave data warrant no practice change; leaves open in vivo relevance for arrhythmia models.
The study provides direct quantitative evidence that calcium waves in mammalian cardiac cells propagate via calcium-induced calcium release mediated by cytosolic diffusion, with smaller peak magnitudes than previously thought.
Takamatsu et al. (1990) studied Mammalian cardiac cells. Dual, digital, indo-1 fluorescence imaging was evaluated on Spatiotemporal origin and propagation of [Ca2+]i waves. High-speed ratiometric imaging revealed that [Ca2+]i waves propagate at a constant velocity of typically 100 microns/s at 22 degrees C, with a spatially steep wave front rising from 500 to 1200 nM.
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