Key result
Intrapericardial nitroglycerin suppressed calcium-induced repolarization heterogeneity and reduced arrhythmia vulnerability, blunting the calcium-induced drop in repetitive extrasystole threshold by 39% (P<0.003).
Why the study?
Does intrapericardial nitroglycerin suppress calcium-induced repolarization heterogeneity and arrhythmia susceptibility in a porcine model?
Population
Anesthetized pigs with autonomic influences minimized by vagotomy and intravenous beta-adrenergic blockade
Comparison
Intrapericardial nitroglycerin prior to… vs Baseline measurements and intracoronary calcium…
Design
Preclinical
Follow-up
30 min
Authors
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Should not change practice; hypothesis-generating for targeted nitroglycerin delivery in arrhythmia models.
Does intrapericardial nitroglycerin suppress calcium-induced repolarization heterogeneity and arrhythmia susceptibility in a porcine model?
p-value: p=<0.003
Intrapericardial nitroglycerin suppresses calcium-induced repolarization heterogeneity and arrhythmia vulnerability independent of autonomic and vasodilatory actions in a porcine model.
Zhao et al. (2006) studied Arrhythmia susceptibility (n=43). Intrapericardial nitroglycerin vs. Baseline / Calcium chloride without nitroglycerin was evaluated on Repetitive extrasystole threshold (RET) and repolarization heterogeneity (p=<0.003). Intrapericardial nitroglycerin suppressed calcium-induced repolarization heterogeneity and reduced arrhythmia vulnerability, blunting the calcium-induced drop in repetitive extrasystole threshold by 39% (P<0.003).
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