Why the study?
Do potassium channel openers (aprikalim, nicorandil) and NO donors (Sin-1) modulate cytosolic calcium transients in rat ventricular myocytes?
Population
Ventricular myocytes isolated from the hearts of adult rats
Comparison
Aprikalim (10 to 10 M), nicorandil (10 to 10 M)… vs Control
Design
Preclinical
Follow-up
10 minutes of pacing
Authors
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Animal data indicate nicorandil's K-ATP effects mask its NO impact on calcium; hypothesis-generating for human myocyte studies.
Do potassium channel openers (aprikalim, nicorandil) and NO donors (Sin-1) modulate cytosolic calcium transients in rat ventricular myocytes?
The NO-donor properties of nicorandil on calcium transients in rat cardiomyocytes are masked by its potassium channel opening effects, becoming apparent only when K-ATP channels are blocked.
Laplace et al. (1999) studied this question.
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