Population
Isolated single rabbit sino-atrial (SA) node cells
Design
Preclinical
Authors
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May caution against bradycardia risk with these agents; leaves open translation from rabbit SA node data to humans.
ATP-sensitive K+ channel openers directly inhibit spontaneous action potentials and Ca2+ currents in rabbit SA node cells, leading to decreased pacemaker activity.
Hiroyasu Satoh (1993) studied this question.
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