Why the study?
Do KATP modulators (cromakalim, pinacidil, glibenclamide) reduce arrhythmias in isolated perfused rat hearts subjected to regional ischaemia?
Population
Isolated perfused rat hearts subjected to regional ischaemia at varying concentrations of external potassium
Comparison
Cromakalim, pinacidil, or glibenclamide given 10… vs Vehicle (0.1% DMSO)
Design
Preclinical
Follow-up
15 min ischaemia and 5 min reperfusion
Authors
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Hypothesis-generating for KATP modulation in ischaemic arrhythmias; prospective studies needed before clinical translation.
Do KATP modulators (cromakalim, pinacidil, glibenclamide) reduce arrhythmias in isolated perfused rat hearts subjected to regional ischaemia?
KATP channel openers and blockers both display potential antiarrhythmic activity during ischaemia in isolated rat hearts, independent of external potassium variations.
D'Alonzo et al. (1994) studied this question.
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