Key result
Transient mechanical alternans in rabbit papillary muscle was induced by lowering temperature and calcium concentration, exposure to 4-aminopyridine, or a shortening step during activity.
Transient mechanical alternans in rabbit papillary muscle appears to be driven by a reduced damping of a regulatory feedback system between inotropic state and activator calcium intake during the action potential.
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Findings from rabbit muscle do not inform clinical alternans management; leaves open in vivo validation of calcium feedback mechanisms.
Björn Wohlfart (1982) studied this question. Lowered temperature and calcium concentration, 4-aminopyridine, or shortening step vs. 37 degrees C, 2.0 mM Ca was evaluated on Transient mechanical alternans (TMA). Transient mechanical alternans in rabbit papillary muscle was induced by lowering temperature and calcium concentration, exposure to 4-aminopyridine, or a shortening step during activity.
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