Key result
Patients with hypertension had significantly higher circulating asymmetric dimethylarginine (ADMA) concentrations compared to normotensive controls (SMD 1.27).
Why the study?
Elevated asymmetric dimethylarginine (ADMA) levels independently predict all-cause mortality, but the role of ADMA in hypertension remains undetermined.
Are circulating ADMA levels elevated in patients with hypertension compared to normotensive controls?
Meta-Analysis (n=2,694)
Are circulating ADMA levels elevated in patients with hypertension compared to normotensive controls?
Standardized Mean Difference: 1.27 (95% CI 0.99–1.54)
p-value: p=<0.001
Circulating ADMA levels are significantly elevated in patients with hypertension compared to normotensive controls, suggesting it may serve as a marker or predictor for hypertensive disease.
Background: Hypertension is the leading risk factor for vascular diseases, such as coronary artery disease, arterial stiffness, and stroke. Elevated asymmetric dimethylarginine (ADMA) levels have been reported to be an independent predictor of all-cause mortality. However, the role of ADMA in hypertension remains undetermined. To derive a more accurate estimate of circulating ADMA levels in hypertension patients, a meta-analysis was performed. Result: The Embase, PubMed, Cochrane Library, and Web of Science databases were searched (up to October 10, 2021) for relevant published literature. To assess study heterogeneity, Cochran’s Q and the I 2 statistic were calculated. Publication bias was evaluated using a funnel plot. A total of 1951 articles were identified, of which 28 studies with 2694 subjects (1534 hypertension patients and 1160 healthy controls) were ultimately included. Plasma/serum ADMA levels were found to be higher in hypertension patients than in healthy controls (standard mean difference = 1.27, 95% confidence interval [0.99, 1.54]). Conclusion: Therefore, strategies aimed at reducing ADMA may constitute an effective therapeutic approach to prevent the development of hypertension in patients.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2022) conducted a meta-analysis in Hypertension (n=2,694). Hypertension vs. Normotension was evaluated on Plasma/serum ADMA levels (SMD 1.27, 95% CI 0.99, 1.54, p=<0.001). Patients with hypertension had significantly higher circulating asymmetric dimethylarginine (ADMA) concentrations compared to normotensive controls (SMD 1.27).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: