Key result
Higher plasma ADMA predicts carotid plaque formation in hypertensive patients.
Why the study?
The relationship between asymmetric dimethylarginine (ADMA) and carotid atherosclerosis in patients with essential hypertension was assessed.
Is asymmetric dimethylarginine (ADMA) associated with carotid atherosclerosis in patients with essential hypertension?
Case-Control (n=364)
Is asymmetric dimethylarginine (ADMA) associated with carotid atherosclerosis in patients with essential hypertension?
Increased levels of ADMA are independently associated with the development of carotid atherosclerosis in patients with essential hypertension.
ADMA may mark carotid atherosclerosis in untreated hypertension; hypothesis-generating and requires prospective validation before clinical consideration.
This study was to assess the relationship between asymmetric dimethylarginine (ADMA) and carotid atherosclerosis in patients with essential hypertension. A total of 182 individuals with never-treated essential hypertension and 182 age-matched healthy controls were studied. Plasma ADMA levels, mean intima-media thickness (IMT) and plaque score were significantly greater in hypertensive patients than normotensive controls. ADMA was positively correlated with mean IMT. On multiple logistic regression analysis, ADMA was a crucial independent predictor of carotid plaque formation (plaque score ≥1.1). Our results suggest that increased levels of ADMA are associated with the development of carotid atherosclerosis in hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Xia et al. (2014) conducted a case-control in Essential hypertension (n=364). Asymmetric dimethylarginine (ADMA) vs. Normotensive controls was evaluated on Carotid atherosclerosis (mean IMT and plaque score). Plasma asymmetric dimethylarginine (ADMA) levels were significantly greater in hypertensive patients than controls and independently predicted carotid plaque formation (plaque score ≥1.1).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: