Key result
Intracoronary doxorubicin infusion of 1 mg/kg in dogs reliably produced an experimental model of accelerated heart failure over 12 weeks, with a 60% survival rate.
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Offers reliable canine model for accelerated HF research; leaves open human translation pending validation.
Shah et al. (1997) studied Chronic heart failure (n=20). Intracoronary doxorubicin was evaluated on Survival at week 12. Intracoronary doxorubicin infusion of 1 mg/kg in dogs reliably produced an experimental model of accelerated heart failure over 12 weeks, with a 60% survival rate.
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