Why the study?
Does the dosing schedule of intravenous doxorubicin affect the severity of cardiomyopathy in experimental animals?
Population
Experimental animals including mice, rats, rabbits and dogs
Comparison
Doxorubicin administered intravenously according… vs Different dosing schedules of doxorubicin
Design
Preclinical
Authors
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Fractionated doxorubicin dosing may reduce cardiomyopathy in animals; leaves open translation to clinical regimens.
Does the dosing schedule of intravenous doxorubicin affect the severity of cardiomyopathy in experimental animals?
Doxorubicin-induced cardiomyopathy is dose-dependent, and its severity can be reduced by administering the drug in lower, repeated doses over a longer period rather than as a high-dose bolus.
Solcia et al. (1981) studied this question.
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