Why the study?
Does doxorubicin-induced chronic cardiac failure alter right ventricular electrophysiological properties in rabbits?
Does doxorubicin-induced chronic cardiac failure alter right ventricular electrophysiological properties in rabbits?
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In a rabbit model of doxorubicin-induced heart failure, shortening of ventricular repolarization and refractory period was observed, suggesting an intrinsic mechanism for arrhythmia predisposition.
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Doherty et al. (1990) studied this question.
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